|
KMID : 0882420080750050592
|
|
Korean Journal of Medicine
2008 Volume.75 No. 5 p.592 ~ p.596
|
|
|
A case of rifampicin-induced interstitial pneumonitis
|
|
Chung Jung-Im
Jung Bock-Hyun
Kim Mi-Hye
Park Yong-Jin
Heo Tae-Yun
Ryui Dae-Sick
Kang Gil-Hyun
|
|
|
Abstract
|
|
|
Rifampicin is a powerful agent for the treatment of pulmonary tuberculosis. However, it may induce several adverse
effects, including rare cases of lung toxicity. Here, we report a case of rifampicin-induced interstitial pneumonitis. A
57-year-old woman diagnosed with cerebellar tuberculoma developed progressive dyspnea after the 5th day of anti-tuberculosis medication. Chest X-ray revealed newly developed ground glass opacities on both lower lung fields. Drug-induced pneumonitis was suspected and all anti-tuberculosis medications were halted. Transbronchial lung biopsy
was consistent with desquamative interstitial pneumonitis. After clinical improvement, a rechallenge test with each anti-tuberculosis medication was attempted. No primary anti-tuberculosis drug except rifampicin triggered recurrence of symptoms, supporting a diagnosis of rifampicin-induced interstitial pneumonitis. Clinicians should be aware of this rare,
but serious, side effect of rifampicin treatment.
|
|
|
KEYWORD
|
|
|
Drug-induced pneumonitis, Rifampicin, Tuberculosis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|